As machine learning gains more and more popularity in science and technology in recent years, scikit-learn becomes one of the must-have libraries in the general machine learning toolbox. In this lecture we will discuss some advanced topic on using scikit-learn python library to make high performance machine learning, specifically the speedup modeling using multicore and accelerators and out-of-core learning. The session assumes the knowledge of topics covered in the first session. Working experience on Python programming, basic machine learning concepts and Scikit-learn will be helpful.